ISPID - International Society for the Study and Prevention of Perinatal and Infant Death
ISPID - International Society for the Study and Prevention of Perinatal and Infant Death

International Society for the Study and Prevention of Perinatal and Infant Death

Stillbirth Research Data Base - Study details

Investigation of the Outcome of Pregnancies Complicated by Increased Fetal Movements (INVEST)

Study Aim This study aims to further understanding about maternal perception of significantly increased fetal movements. It will explore whether increased fetal movements is associated with abnormalities of placental and cord and to investigate which clinical investigations predict adverse pregnancy outcome in women following maternal perception of increased fetal movement.
Study Design/Methods This is a cohort study of women presenting with increased fetal movements. Women who have one episode of significantly increased fetal movement will be approached to participate. Participants will have an ultrasound scan and blood test at the time of presentation. Information will be collected about the outcome of the pregnancy. The placenta will be collected after delivery for delivery examination.
Countries of Recruitment United Kingdom
Target number of participants 200
Short synopsis A mothers’ perception of her baby's movements has been used to confirm fetal wellbeing for many years. Studies have shown that a significant reduction in babies' movements is associated with poor pregnancy outcomes including increased risk of stillbirth, poor fetal growth and premature labour. Experiments in our laboratory demonstrated that mothers’ perception of reduced fetal movements was associated with abnormalities of placental structure and function. Furthermore, we found that adverse pregnancy outcome was predicted by small fetal size and low liquor volume on ultrasound scan and low levels of placental hormones in maternal blood. These observations have formed the basis of a clinical trial to better detect babies at risk following maternal perception of reduced fetal movement.In addition to reduced fetal movements, two recent studies of women who had experienced a stillbirth also found that a single period of significantly increased fetal activity was also associated with stillbirth. In contrast to reduced fetalmovements there is little information currently about what women should do if they perceive a significant increase in fetal activity, what the increase in fetal movements might represent and whether it is associated with any underlyingproblems of the placenta or cord. In this study we will recruit women attending with significantly increased fetal movements. We will collect information about the outcome of these pregnancies, the results of the fetal heart rate monitoring and an ultrasound scan. We will also ask women to donate their placenta and cord for study to determine whether the placenta and cord differs from women with normal fetal movements.This study will recruit all women who present with increased fetal movements after 28 weeks of pregnancy. We estimate that women experience in up to 2% of pregnancies; thus in the 12 months recruitment phase we anticipate up to 200 participants in the study.
Funding sources Mitchell Family Charitable TrustTommy's
Ethics Board Approval Greater Manchester East Research Ethics Committee Reference 17/NW/0229
Study contact name Professor Alexander Heazell
Contact email alexander.heazell@manchester.ac.uk
Sponsoring organizations University of Manchester, UK
Collaborators Dr Andrew Sharp, University of Liverpool, UK.
Status In Progress
(expected) Year of completion 2019
Citation details of journal articles None as yet.
Additional Comments

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