ISPID - International Society for the Study and Prevention of Perinatal and Infant Death
ISPID - International Society for the Study and Prevention of Perinatal and Infant Death

International Society for the Study and Prevention of Perinatal and Infant Death

Stillbirth Research Data Base - Study details

Estimated Placental Volume ResearchKit App Study

Study Aim The Estimated Placental Volume (EPV) app uses ResearchKit, a software framework designed by Apple, to empower women to contribute to research that will help decrease the chance of a pregnancy loss due to an undersized placenta.
Study Design/Methods The ultimate goal of the EPV ResearchKit app project is to see if EPV measurements can predict pregnancy outcome and to generate sufficient data to convince healthcare providers who care for pregnant women to incorporate EPV measurements into their routine prenatal care.
Countries of Recruitment USA
Target number of participants
Short synopsis EPV is a ResearchKit app that allows patients to follow the growth of their baby’s placenta (the fetal organ that acts like the roots of a tree, bringing nutrients and oxygen from the mother to the developing fetus). By participating in this study pregnant women can help researchers to understand normal and abnormal placental growth. Once the patient is found to be eligible to join the study and signs the consent form, the Estimated Placental Volume (EPV) can be determined whenever the participant undergoes an ultrasound examination during their pregnancy. At the completion of the pregnancy the patient is asked to report on the pregnancy outcome. No personal information is stored or transmitted to the researchers. All information is transmitted in an encrypted manner and stored as anonymous data on a secure server. The EPV app calculates the Estimated Placental Volume (EPV) from 2D ultrasounds of the human placenta (1). The user interface calculates EPV and then plots the resultant value on a graphical plot. As new values are collected, they are added to the graph. The user can select any of the values to see what the gestational age was at the time of data collection and the EPV for that exam. Using a simple 2D ultrasound cross-section of the major axis of a placenta from 7 to 45 weeks of gestation the Estimated Placental Volume (EPV) can be calculated from three simple measurements: maximal width, height at maximal width and thickness along the same line as the height. Measurements are recorded in centimeters. Physicians, nurse midwives, ultrasound technicians and other health care providers can assist the patient use this application to follow placental growth during gestation.
Funding sources Reproductive and Placental Research Unit, Yale University School of Medicine.
Ethics Board Approval Yale University Human Investigation Committee protocol 09050051579248.
Study contact name Harvey Kliman, MD, PhD
Contact email harvey.kliman@yale.edu
Sponsoring organizations Yale University
Collaborators Harvey Kliman, Yale University
Status 0
(expected) Year of completion 2020
Citation details of journal articles Azpurua HJ, Funai EF, Coraluzzi L, Sasson I, Doherty L, Kliman M, Kliman HJ. Determination of placental weight using two-dimensional sonography and volumetric mathematic modeling, Am J Perinatology, 27: 151-155, 2010. Kliman HJ, Arleo EK, Troiano RN. Development of In Utero Normative Placental Growth Curves Using a Validated Mathematical Model, ACOG 59th Annual Meeting, April 30 to May 4, 2011, Washington, DC Staff AC, Laine K, Lahmami G, Gustafsson J, Surbehan H, Barbero ML, Kliman HJ. Second trimester estimated placental volume (EPV) screening is predictive of SGA and LGA at birth. International Federation of Placenta Associations, September 13-17, 2008, Geilo, Norway. Arleo EK, Troiano RN, da Silva R, Greenbaum D, Hartigan JA, Ge W, Zeissler AG, Kliman HJ. Estimated Placental Volume (EPV): Set a Competitive New Standard of Prenatal Care in Less Than One Minute. Radiologic Society of North America, November 27-December 2, Chicago, IL. Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Utilizing 2-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume (EPV). Am J Perinatology. 2013 Oct 9. [Epub ahead of print]
Additional Comments Link to EPV ResearchKit app: https://itunes.apple.com/us/app/epv/id1031035790?mt=8

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